HCID 68601184, compound → HCID 68600497, compound

HRID 1185536Notes

Reaction equation

HRID 1185536 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C@@H:13]([NH:18]C(OCC2C=CC=CC=2)=O)[CH2:14][CH:15]([F:17])[F:16])[CH2:8][CH2:7]1)=[O:5])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C@@H:13]([NH2:18])[CH2:14][CH:15]([F:17])[F:16])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 68601184HCID 68601184, compound

Product 1

HCID 68600497HCID 68600497, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 168 mg 4-((S)-2-Benzyloxycarbonylamino-4,4-difluoro-butyryl)-piperazine-1-carboxylic acid ethyl ester in 15 ml ethyl acetate were added 100 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (1 bar) for 1 h. The reaction mixture was filtrated over a plug of Celite®, washed with ethyl acetate and concentrated. Yield: 100 mg colorless oil

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite®
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-22264a1d9b0e45109567155ee4c54436
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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