HCID 68599828, compound → HCID 68598101, compound

HRID 1185538Notes

Reaction equation

HRID 1185538 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:31])[C@@H:15]([NH:20]C(OCC2C=CC=CC=2)=O)[CH2:16][CH:17]([F:19])[F:18])[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:31])[C@@H:15]([NH2:20])[CH2:16][CH:17]([F:18])[F:19])[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 68599828HCID 68599828, compound

Product 1

HCID 68598101HCID 68598101, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 168 mg 4-((S)-2-Benzyloxycarbonylamino-4,4-difluoro-butyryl)-piperazine-1-carboxylic acid butyl ester in 15 ml ethyl acetate were added 100 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (1 bar) for 1 h. The reaction mixture was filtrated over a plug of Celite®, washed with ethyl acetate and concentrated. Yield: 97 mg colorless oil

Workup

  1. filtrationThe reaction mixture was filtrated over a plug of Celite®
  2. washwashed with ethyl acetate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-4a417364263a4dd79aabee2c5b1048c6
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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