HCID 68599078, compound → 4-Carboxymethoxy-7-methyl-quinoline-2-carboxylic acid methyl ester

HRID 1185578Notes

Reaction equation

HRID 1185578 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([O:15][CH2:16][C:17]([O:19]CC2C=CC=CC=2)=[O:18])[C:12]2[C:7](=[CH:8][C:9]([CH3:27])=[CH:10][CH:11]=2)[N:6]=1)=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([O:15][CH2:16][C:17]([OH:19])=[O:18])[C:12]2[C:7](=[CH:8][C:9]([CH3:27])=[CH:10][CH:11]=2)[N:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 68599078HCID 68599078, compound

Product 1

HCID 685989324-Carboxymethoxy-7-methyl-quinoline-2-carboxylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3.00 g 4-Benzyloxycarbonylmethoxy-7-methyl-quinoline-2-carboxylic acid methyl ester in 50 ml ethanol were added under argon 0.3 g Pd/C (10%) and the suspension was stirred under an atmosphere of hydrogen (3 bar) for 16 h. The suspension was filtered over a plug of Celite® and washed with ethanol. The crude product was obtained after evaporation of the solvent. Yield: 1.90 g.

Workup

  1. filtrationThe suspension was filtered over a plug of Celite®
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-48306bd95ebb44f087f8edfcdfb127cf
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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