反应详情

To a solution of 815 mg 4-[2-(3,3-Difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carboxylic acid methyl ester in 8 ml THF were added 2.2 ml aqueous NaOH (1 M) at 0° C. After 2 h the mixture was brought to pH 4 by using Amberlite IR-120 ion exchange resin. The reaction mixture was filtered and concentrated and the crude product obtained used in the next step without further purification. Yield: 658 mg.

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated