Hydrochloric Acid → Ethyl 2-amino-2-(4-bromophenyl)propanoate

HRID 1185611노트

반응식

HRID 1185611 반응식
[NH2:1][C:2]([C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)([CH3:6])[C:3]([OH:5])=[O:4].Cl.[CH2:15](O)[CH3:16]>>[CH2:15]([O:4][C:3](=[O:5])[C:2]([NH2:1])([C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[CH3:6])[CH3:16]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 31587702-Amino-2-(4-bromophenyl)propanoic acid

생성물 1

HCID 3494252Ethyl 2-amino-2-(4-bromophenyl)propanoate수율 72%

실험 절차

To a solution of 2-amino-2-(4-bromo-phenyl)-propionic acid (1.0 g, 4.1 mmol) in ethanol (20 mL) was bubbled through HCl gas for five minutes. The mixture was stirred at ambient for 24 hours, then refluxed for 18 hours. The volatile component was removed in vacuo, and the residue was dissolved in ethyl acetate (150 mL), washed with NaHCO3 solution, water and brine, dried over MgSO4, filtered and concentrated in vacuo. The obtained residue was purified by flash chromatography to provide the desired product (800 mg, 72%). m/z 271.7, 273.7 (M+H)+.

후처리

  1. temperaturerefluxed for 18 hours
  2. customThe volatile component was removed in vacuo
  3. dissolutionthe residue was dissolved in ethyl acetate (150 mL)
  4. washwashed with NaHCO3 solution, water and brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customThe obtained residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-229ad93c4cd04596bc78cc2c125ccf81
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08669234B2

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