Hydrochloric Acid → HCID 54033258, compound

HRID 1186008Notes

Reaction equation

HRID 1186008 reaction equation
[OH:1][CH2:2][C@H:3]([NH:8][C:9]([C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1C(OC(C)(C)C)=O)=[O:10])[C:4]([O:6][CH3:7])=[O:5].Cl>O1CCOCC1>[OH:1][CH2:2][C@H:3]([NH:8][C:9]([C@@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)=[O:10])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11616671HCID 11616671, compound

Product 1

HCID 54033258HCID 54033258, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

(S)-Tert-butyl-2-((S)-3-hydroxy-1-methoxy-1-oxopropan-2-ylcarbamoyl)-pyrrolidine-1-carboxylate (3) (500 mg, 1.58 mmol) was dissolved in 1,4-dioxane (3 mL) and a HCl solution in dioxane (3.16 mL, 3.16 mmol) was added stirred at RT for 4 h. The volatiles were evaporated under reduced pressure to afford compound 4 (280 mg) as solid.

Workup

  1. customThe volatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-6f9aba53cec84080a03daab7516d0eef
Source dataset
uspto-grants-2014_03
Patent number
US08673843B2

Reaction notes

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