Ammonia methanol → HCID 131731245, compound

HRID 1186010Notes

Reaction equation

HRID 1186010 reaction equation
C([O:4][C@@H:5]([CH3:42])[C@@H:6]([NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[C:7]([N:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[C:14]([N:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[C:21]([NH:23][C@@H:24]([CH2:29][OH:30])[C:25]([O:27]C)=[O:26])=[O:22])=[O:15])=[O:8])(=O)C.CO.[NH3:45]>CO>[CH2:35]([O:34][C:32](=[O:33])[NH:31][C@H:6]([C@@H:5]([OH:4])[CH3:42])[C:7]([N:9]1[CH2:13][CH2:12][CH2:11][C@H:10]1[C:14]([N:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[C:21](=[O:22])[NH:23][C@@H:24]([CH2:29][OH:30])[C:25]([O:27][NH2:45])=[O:26])=[O:15])=[O:8])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 71245451HCID 71245451, compound

Product 1

HCID 131731245HCID 131731245, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of compound 6 (250 g, 0.42 mmol) in CH3OH (2 mL) was added MeOH—NH3 (10 mL) and was stirred at RT for 16 h. The volatiles were evaporated under reduced pressure to afford compound 7 (190 mg, 84%).

Workup

  1. customThe volatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-36ee3a6efa6d432fa99ae504ff9df0f4
Source dataset
uspto-grants-2014_03
Patent number
US08673843B2

Reaction notes

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