Ammonia methanol → HCID 71250018, compound

HRID 1186013Notes

Reaction equation

HRID 1186013 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:37][OH:38])[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][C@H:16]1[C:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[C:27]([NH:29][C@@H:30]([CH2:35][OH:36])[C:31]([O:33]C)=O)=[O:28])=[O:21])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.[NH3:41]>CO>[CH2:1]([O:8][C:9](=[O:10])[NH:11][C@@H:12]([CH2:37][OH:38])[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][C@H:16]1[C:20]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[C:27](=[O:28])[NH:29][C@@H:30]([CH2:35][OH:36])[C:31]([NH2:41])=[O:33])=[O:21])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 71245299HCID 71245299, compound

Product 1

HCID 71250018HCID 71250018, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (S)-methyl-2-((S)-1-((S)-1-((S)-2-(benzyloxycarbonylamino)-3-hydroxypropanoyl)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carboxamido)-3-hydroxypropanoate (6) (60 mg, 1.04 mmol) in MeOH was added MeOH—NH3 (3 mL) was stirred at RT for 16 h. The volatiles were evaporated under reduced pressure to afford compound 7 (30 mg, 55%).

Workup

  1. customThe volatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-96f7b3c042e843b7af07a244bed33678
Source dataset
uspto-grants-2014_03
Patent number
US08673843B2

Reaction notes

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