反应详情

(2-Bromo-4,5-dimethoxy-phenyl)-methanol (25.09 g, 0.1015 mol) was added as a solid to a vigorously stirred solution of concentrated aqueous HCl (75 mL). The resulting white suspension was stirred at room temperature for 30 min. The resulting mixture was then extracted with CH2Cl2 (3×) and the combined extracts dried over MgSO4, filtered and concentrated in vacuo to yield 1-bromo-2-chloromethyl-4,5-dimethoxy-benzene as a white solid.

1. extractionThe resulting mixture was then extracted with CH2Cl2 (3×)
2. dry with materialthe combined extracts dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo