反应详情

2,3-Dimethyl-buta-1,3-diene (2.0 g, 24.3 mmol) and but-2-ynedioic acid dimethyl ester in benzene (14 mL) were heated to reflux for 16 h. The resulting mixture was cooled and evaporated in vacuo to yield a solid, which was purified via flash column chromatography (EtOAc/heptane 9:1) to yield 4,5-dimethyl-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester as a white solid.

1. temperatureto reflux for 16 h
2. temperatureThe resulting mixture was cooled
3. customevaporated in vacuo
4. customto yield a solid, which
5. customwas purified via flash column chromatography (EtOAc/heptane 9:1)