反应详情

To 8-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione (0.8 g, 4.1 mmol) in anhydrous methanol (25 mL), was added sodium hydroxide (0.24 g, 4.1 mmol) and the mixture was heated to reflux for 2 hours. The solution was cooled, diluted with ethyl acetate, washed with water, saturated sodium bicarbonate, then brine, and dried with sodium sulfate. It was filtered and concentrated to yield methyl 2-amino-3-methoxybenzoate (750 mg, 100%).

1. temperaturethe mixture was heated
2. temperatureto reflux for 2 hours
3. temperatureThe solution was cooled
4. washwashed with water, saturated sodium bicarbonate
5. dry with materialbrine, and dried with sodium sulfate
6. filtrationIt was filtered
7. concentrationconcentrated