反应详情

Methyl 2-amino-5-chloro-3-methoxybenzoate (770 mg, 3.57 mmol) was suspended in tetrahydrofuran (20 mL), 2M sodium hydroxide (5 mL) was added and the mixture was stirred at ambient temperature for 20 hours. The solution was concentrated in vacuo, then partitioned between ethyl acetate and 1M hydrochloric acid. The organic layer was washed with water, then brine, dried with sodium sulfate, decanted and concentrated in vacuo to yield 2-amino-5-chloro-3-methoxybenzoic acid.

1. concentrationThe solution was concentrated in vacuo
2. custompartitioned between ethyl acetate and 1M hydrochloric acid
3. washThe organic layer was washed with water
4. dry with materialbrine, dried with sodium sulfate
5. customdecanted
6. concentrationconcentrated in vacuo