反应详情

The compound obtained in Example 25-1 (266.6 mg) was dissolved in THF (2.7 ml) and methanol (2.7 ml). After the addition of 1 mol/l aqueous solution of sodium hydroxide (2.7 ml), the mixture was stirred for 5 hours at room temperature. After the reaction, the solvent was removed by distillation. The residue was dissolved in distilled water and 1 mol/l aqueous solution of hydrochloric acid was added to produce a precipitate. The precipitate was collected by filtration and dried to obtain the title compound (233.5 mg) as a white solid.

1. customAfter the reaction
2. customthe solvent was removed by distillation
3. dissolutionThe residue was dissolved in distilled water
4. addition1 mol/l aqueous solution of hydrochloric acid was added
5. customto produce a precipitate
6. filtrationThe precipitate was collected by filtration
7. customdried