反应详情

To a solution of 2-methyl-2-(4-nitrophenyl)-propionic acid methyl ester (932.2 mg, 4.16 mmol) and ammonium formate (1.58 g, 25.1 mmol) in MeOH was added Pd/C (10%, 441.2 mg, 0.414 mmol). The reaction mixture was stirred at rt until gas evolution ceased, then filtered through a plug of diatomaceous earth and concentrated. The residue was redissolved in H2O and extracted with EtOAc. The organic layers were combined, dried, and concentrated to provide the title compound which was used without further purification.

1. filtrationfiltered through a plug of diatomaceous earth
2. concentrationconcentrated
3. dissolutionThe residue was redissolved in H2O
4. extractionextracted with EtOAc
5. customdried
6. concentrationconcentrated