5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → HCID 86660410, compound

HRID 1186150Notes

Reaction equation

HRID 1186150 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[CH2:14][C:13]([CH3:16])([CH3:15])[O:12][CH2:11][C:10](=[S:17])[NH:9]2)[CH:7]=1.[F:20][C:21]([F:34])([F:33])[CH2:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([C:30](O)=[O:31])=[N:28][CH:29]=1>>[F:19][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:30]([C:27]2[CH:26]=[CH:25][C:24]([O:23][CH2:22][C:21]([F:34])([F:33])[F:20])=[CH:29][N:28]=2)=[O:31])=[CH:7][C:6]=1[C@:8]1([CH3:18])[CH2:14][C:13]([CH3:16])([CH3:15])[O:12][CH2:11][C:10](=[S:17])[NH:9]1

Participants

3

Reactant 2

HCID 574758545-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid2×HCID 58562953HCID 58562953, compound

Product 1

HCID 86660410HCID 86660410, compound

Procedure

The title compound was prepared in an analogous manner as described for intermediate B14A from (S)-5-(5-amino-2-fluoro-phenyl)-5,7,7-trimethyl-[1,4]oxazepane-3-thione (intermediate A′7A) (108 mg, 0.38 mmol) and 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [CAS No. 881409-53-6; described in intermediate 49] (94 mg, 0.43 mmol). The compound was obtained as a light yellow foam (156 mg, 76%). MS (ISP): m/z=486.3 [(M+H)+].

Sources & evidence

ORD record
ord-ac3bf220c44e4637bd6a488aabf4c8d1
Source dataset
uspto-grants-2014_03
Patent number
US08673894B2

Reaction notes

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