HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → (R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(ethoxymethyl)picolinamide formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine | HCID 58562966 | — |
| Reactant | 5-Ethoxymethyl-pyridine-2-carboxylic acid | HCID 67025644 | — |
| Product | (R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(ethoxymethyl)picolinamide formate | HCID 54577793 | — |
Reaction Steps
The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 5-ethoxymethyl-pyridine-2-carboxylic acid (which might be prepared in analogy to the isopropyl ether described by Robert M. et al., Int. Patent Application Publ. No. WO2005007658) yielded the title compound as a white solid. MS (ISP): m/z=437.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673894B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-a236cda1856242b9b0cb2f1899c40101 |
| Source note | uspto-grants-2014_03 |