Diisopropyl Ether → HCID 54577793, compound

HRID 1186197Notes

Reaction equation

HRID 1186197 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C@:8]2([CH3:18])[C:14]([F:16])([F:15])[CH2:13][O:12][CH2:11][C:10]([NH2:17])=[N:9]2)[CH:7]=1.[CH2:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([C:30]([OH:32])=[O:31])=[N:28][CH:29]=1)[CH3:21].C(OC(C)C)(C)C>>[CH:30]([OH:32])=[O:31].[NH2:17][C:10]1[CH2:11][O:12][CH2:13][C:14]([F:15])([F:16])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:30](=[O:31])[C:27]3[CH:26]=[CH:25][C:24]([CH2:23][O:22][CH2:20][CH3:21])=[CH:29][N:28]=3)[CH:3]=[CH:4][C:5]=2[F:19])([CH3:18])[N:9]=1

Participants

4

Reactant 3

HCID 7914Diisopropyl EtherHCID 58562966(R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amineHCID 67025644HCID 67025644, compound

Product 1

HCID 54577793HCID 54577793, compound

Procedure

The coupling of (R)-5-(5-amino-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine (intermediate A10A) and 5-ethoxymethyl-pyridine-2-carboxylic acid (which might be prepared in analogy to the isopropyl ether described by Robert M. et al., Int. Patent Application Publ. No. WO2005007658) yielded the title compound as a white solid. MS (ISP): m/z=437.2 [M+H]+.

Sources & evidence

ORD record
ord-a236cda1856242b9b0cb2f1899c40101
Source dataset
uspto-grants-2014_03
Patent number
US08673894B2

Reaction notes

Loading…