5-fluoropyridine-2-carboxylic Acid → HCID 54578012, compound

HRID 1186201Notes

Reaction equation

HRID 1186201 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:23])=[C:6]([C@:8]2([CH3:22])[CH2:14][C@@H:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:12][CH2:11][C:10]([NH2:21])=[N:9]2)[CH:7]=1.[F:24][C:25]1[CH:26]=[CH:27][C:28]([C:31](O)=[O:32])=[N:29][CH:30]=1>>[NH2:21][C:10]1[CH2:11][O:12][C@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:14][C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:31]([C:28]3[CH:27]=[CH:26][C:25]([F:24])=[CH:30][N:29]=3)=[O:32])[CH:3]=[CH:4][C:5]=2[F:23])([CH3:22])[N:9]=1

Participants

3

Reactant 2

HCID 27628765-fluoropyridine-2-carboxylic AcidHCID 58562973HCID 58562973, compound

Product 1

HCID 54578012HCID 54578012, compound

Procedure

The compound was prepared in an analogous manner as described for the preparation of the amides Ia from (5S ,7S)-5-(5-Amino-2-fluoro-phenyl)-5-methyl-7-phenyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine (intermediate A10G) and 5-fluoropyridine-2-carboxylic acid. The title compound was obtained as a white solid. MS (ISP): m/z=437.3 [(M+H)+].

Workup

  1. customThe compound was prepared in an analogous manner

Sources & evidence

ORD record
ord-e56ecce9a2fe46fa95856cb5d74f083e
Source dataset
uspto-grants-2014_03
Patent number
US08673894B2

Reaction notes

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