Azd-8848 → methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride

Participants

Reaction Steps

Methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate (40 mg, 0.07 mmol) was dissolved in ethyl acetate (5 mL) and 3.28M HCl/ethanol solution (21 μL, 0.07 mmol) was added. The solvent was removed by evaporation and the residue was dried in vacuo to give methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride as the final product.

Provenance & Evidence