HRID1186252

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCCN3CCOCC3)Cc3cccc(CC(=O)OC)c3)c2n1

HCID11592228

未命名化合物

HCID21887872

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCCN3CCOCC3)Cc3cccc(CC(=O)OC)c3)c2n1.Cl

HCID44128977

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate (40 mg, 0.07 mmol) was dissolved in ethyl acetate (5 mL) and 3.28M HCl/ethanol solution (21 μL, 0.07 mmol) was added. The solvent was removed by evaporation and the residue was dried in vacuo to give methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride as the final product.

WORKUP

后处理

customThe solvent was removed by evaporation
customthe residue was dried in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0010b5a35d9d4c29a58cc9fbb3c572ad
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08673907B2
来源说明: uspto-grants-2014_03

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.[ClH:42].C(O)C>C(OCC)(=O)C>[ClH:42].[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1