Azd-8848 → methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride

HRID 1186252Notes

Reaction equation

HRID 1186252 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.[ClH:42].C(O)C>C(OCC)(=O)C>[ClH:42].[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:41])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:29][C:30]1[CH:31]=[C:32]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:34][CH:35]=1)[CH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 11592228Azd-8848HCID 21887872Ethanol hydrochloride

Product 1

HCID 44128977methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate (40 mg, 0.07 mmol) was dissolved in ethyl acetate (5 mL) and 3.28M HCl/ethanol solution (21 μL, 0.07 mmol) was added. The solvent was removed by evaporation and the residue was dried in vacuo to give methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride as the final product.

Workup

  1. customThe solvent was removed by evaporation
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-0010b5a35d9d4c29a58cc9fbb3c572ad
Source dataset
uspto-grants-2014_03
Patent number
US08673907B2

Reaction notes

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