反应详情

温度

60 °C

A 80 mM solution of hydrochloric acid in methanol (65.0 μl, 5.2 μmol) was added to a solution of methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate (3.0 mg, 5.3 μmol) dissolved in methanol (1.5 ml) at room temperature. The solution was shaken at 60° C. for one hour, then cooled to 5° C. After 30 minutes, the solvent was left to slowly evaporate at 5° C., to give methyl (3-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl}phenyl)acetate monohydrochloride as the final product.

1. temperaturecooled to 5° C
2. waitAfter 30 minutes
3. waitthe solvent was left
4. customto slowly evaporate at 5° C.