Hydrochloric Acid → HCID 86657931, compound

Participants

Reaction Steps

2-Chloro-3-[2,2,2-trifluoro-1-(1-tert-butoxycarbonyl-4-fluoropiperidin-4-yl)ethoxy]quinoxaline (367 mg, 0.797 mmol) was dissolved in methanol (4.0 mL). To this, a 10% solution of hydrogen chloride in methanol (4.0 mL) was added and the mixture was stirred at room temperature for 1 hour. The mixture was further stirred at 50° C. for 1 hour and the solvent was evaporated off under reduced pressure. Thus, 2-chloro-3-[2,2,2-trifluoro-1-(4-fluoropiperidin-4-yl)-ethoxy]quinoxaline hydrochloride (334 mg, yield: 100%) was obtained.

Provenance & Evidence