Hydrochloric Acid → HCID 86657931, compound

HRID 1186320Notes

Reaction equation

HRID 1186320 reaction equation
[Cl:1][C:2]1[C:11]([O:12][CH:13]([C:18]2([F:31])[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[C:14]([F:17])([F:16])[F:15])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[C:11]([O:12][CH:13]([C:18]2([F:31])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:14]([F:15])([F:16])[F:17])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86657933HCID 86657933, compound

Product 1

HCID 86657931HCID 86657931, compoundYield 209.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2-Chloro-3-[2,2,2-trifluoro-1-(1-tert-butoxycarbonyl-4-fluoropiperidin-4-yl)ethoxy]quinoxaline (367 mg, 0.797 mmol) was dissolved in methanol (4.0 mL). To this, a 10% solution of hydrogen chloride in methanol (4.0 mL) was added and the mixture was stirred at room temperature for 1 hour. The mixture was further stirred at 50° C. for 1 hour and the solvent was evaporated off under reduced pressure. Thus, 2-chloro-3-[2,2,2-trifluoro-1-(4-fluoropiperidin-4-yl)-ethoxy]quinoxaline hydrochloride (334 mg, yield: 100%) was obtained.

Workup

  1. stirringThe mixture was further stirred at 50° C. for 1 hour
  2. customthe solvent was evaporated off under reduced pressure

Sources & evidence

ORD record
ord-bf5a826ee4b34ab8991decea62000535
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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