Chloroacetyl chloride → HCID 65312466, compound

2-Amino-1,3-propanediol (5.24 g, 57.5 mmol) was dissolved in a mixed solvent (220 mL) of acetonitrile/methanol (6/1). To this, triethylamine (9.60 mL, 69.6 mmol) and chloroacetyl chloride (5.10 mL, 63.3 mmol) were successively added under ice-cooling, and the mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was evaporated off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol=90/10) to give 2-chloro-N-(2-hydroxy-1-hydroxymethylethyl)acetamide (8.30 g, yield: 86%).

1. temperaturecooling
2. customAfter completion of the reaction
3. customthe solvent was evaporated off under reduced pressure
4. customThe residue was purified by silica gel column chromatography (ethyl acetate/methanol=90/10)

ORD record

ord-fe5c006f16b74acaa57ce3c23b4ef260

Source dataset

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08673908B2