HCID 67401333, compound → HCID 67401446, compound

HRID 1186394Notes

Reaction equation

HRID 1186394 reaction equation
[CH3:1][C:2](=[CH:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]>C(O)C.[C].[Pd]>[CH3:1][CH:2]([CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

4

Reactant 1

HCID 67401333HCID 67401333, compound

Product 1

HCID 67401446HCID 67401446, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Ethyl 2-methyl-3-(pyridin-3-yl)acrylate (480 mg, 2.4 mmol) obtained in Step 1 of Reference Example 8-65 was dissolved in ethanol (5 mL). To this, 10% palladium carbon (92 mg) was added under an argon atmosphere, and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered through Celite and the solvent in the filtrate was evaporated off under reduced pressure. Thus, ethyl 2-methyl-3-(pyridin-3-yl)propanoate (453 mg, yield: 98%) was obtained.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent in the filtrate was evaporated off under reduced pressure

Sources & evidence

ORD record
ord-aff4573d051e4299b16f0aacc752b806
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

Loading…