HCID 67401333, compound → HCID 67401446, compound

Participants

Reaction Steps

Ethyl 2-methyl-3-(pyridin-3-yl)acrylate (480 mg, 2.4 mmol) obtained in Step 1 of Reference Example 8-65 was dissolved in ethanol (5 mL). To this, 10% palladium carbon (92 mg) was added under an argon atmosphere, and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered through Celite and the solvent in the filtrate was evaporated off under reduced pressure. Thus, ethyl 2-methyl-3-(pyridin-3-yl)propanoate (453 mg, yield: 98%) was obtained.

Provenance & Evidence