Methyl iodide → HCID 67401538, compound

HRID 1186408Notes

Reaction equation

HRID 1186408 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[I:12]C>ClCCl>[I-:12].[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[NH+:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 2956613-(1,3-dioxolan-2-yl)pyridine

Product 1

HCID 67401538HCID 67401538, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(1,3-Dioxolan-2-yl)pyridine (1.00 g, 6.62 mmol) was dissolved in dichloromethane (20.0 mL). To this, iodomethane (494 μL, 7.94 mmol) was added under a nitrogen atmosphere at room temperature and the mixture was stirred at room temperature for 72 hours. The reaction mixture was concentrated, and the residue was subjected to slurry purification using diisopropyl ether, to give 3-(1,3-dioxolan-2-yl)-1-pyridinium iodide (1.85 g, yield: 96%).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurification

Sources & evidence

ORD record
ord-52edd2d49e7e4f7c9cc2e60c05fff3b9
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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