Water → HCID 67402290, compound

Participants

Reaction Steps

By use of 1-acetyl-4-fluoro-4-[2,2,2-trifluoro-1-(triethylsiloxy)-ethyl]piperidine (294 mg, 0.822 mmol) dissolved in tetrahydrofuran (5 mL) and a 1 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (1.23 mL, 1.23 mmol), the mixture was stirred and reacted at room temperature for 30 minutes. The reaction was stopped by addition of water to the reaction mixture, and extraction with ethyl acetate was performed, followed by drying over anhydrous sodium sulfate.

Provenance & Evidence