Water → HCID 67402290, compound

HRID 1186431Notes

Reaction equation

HRID 1186431 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]([F:23])([CH:10]([O:15][Si](CC)(CC)CC)[C:11]([F:14])([F:13])[F:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.O.C(OCC)(=O)C>O1CCCC1>[C:1]([N:4]1[CH2:5][CH2:6][C:7]([F:23])([CH:10]([OH:15])[C:11]([F:13])([F:12])[F:14])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 2724141Tetrabutylammonium FluorideHCID 67402531HCID 67402531, compound

Product 1

HCID 67402290HCID 67402290, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

By use of 1-acetyl-4-fluoro-4-[2,2,2-trifluoro-1-(triethylsiloxy)-ethyl]piperidine (294 mg, 0.822 mmol) dissolved in tetrahydrofuran (5 mL) and a 1 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (1.23 mL, 1.23 mmol), the mixture was stirred and reacted at room temperature for 30 minutes. The reaction was stopped by addition of water to the reaction mixture, and extraction with ethyl acetate was performed, followed by drying over anhydrous sodium sulfate.

Workup

  1. customreacted at room temperature for 30 minutes
  2. dry with materialby drying over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-3c201c034a3f410c994fe22fde02125a
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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