Ammonia → 1,2-dimethyl-1H-imidazole-4-sulfonamide

HRID 1186435Notes

Reaction equation

HRID 1186435 reaction equation
[NH3:1].[CH3:2][N:3]1[CH:7]=[C:6]([S:8](Cl)(=[O:10])=[O:9])[N:5]=[C:4]1[CH3:12]>CO>[CH3:2][N:3]1[CH:7]=[C:6]([S:8]([NH2:1])(=[O:10])=[O:9])[N:5]=[C:4]1[CH3:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27362561,2-Dimethylimidazole-4-sulfonyl chloride

Product 1

HCID 27585631,2-dimethyl-1H-imidazole-4-sulfonamideYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 7 mol/L solution of ammonia in methanol (2 mL) was added to 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (200 mg, 1.7 mmol) and the mixture was stirred at room temperature for 4 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and thereby 1,2-dimethyl-1H-imidazole-4-sulfonamide (Compound FG) (54 mg, yield: 60%) was obtained.

Workup

  1. customThe solvent in the reaction mixture was evaporated off under reduced pressure

Sources & evidence

ORD record
ord-f305bbe339304e27bbb778a94681e1fa
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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