Ammonia → 1,2-dimethyl-1H-imidazole-4-sulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	1,2-Dimethylimidazole-4-sulfonyl chloride	HCID 2736256	—
Solvent	Methanol	HCID 887	—
Product	1,2-dimethyl-1H-imidazole-4-sulfonamide	HCID 2758563	60%

Reaction Steps

A 7 mol/L solution of ammonia in methanol (2 mL) was added to 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (200 mg, 1.7 mmol) and the mixture was stirred at room temperature for 4 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and thereby 1,2-dimethyl-1H-imidazole-4-sulfonamide (Compound FG) (54 mg, yield: 60%) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673908B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-f305bbe339304e27bbb778a94681e1fa
Source note	uspto-grants-2014_03