Morpholine → 4-Morpholinesulfonamide

Participants

Reaction Conditions

Reaction Steps

Tetrahydrofuran (3 mL) and morpholine (0.68 mL, 7.8 mmol) were added to sulfamide (500 mg, 5.2 mmol) and the mixture was stirred at 100° C. for 4 hours. The solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (chloroform/methanol=1/0 to 4/1) was performed to give morpholine-4-sulfonamide (Compound FY) (67 mg, yield: 8%).

Provenance & Evidence