Morpholine → 4-Morpholinesulfonamide

HRID 1186440Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[S:7](N)([NH2:10])(=[O:9])=[O:8]>O1CCCC1>[N:1]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

Conditions

Temperature: 100 °C

Procedure

Tetrahydrofuran (3 mL) and morpholine (0.68 mL, 7.8 mmol) were added to sulfamide (500 mg, 5.2 mmol) and the mixture was stirred at 100° C. for 4 hours. The solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (chloroform/methanol=1/0 to 4/1) was performed to give morpholine-4-sulfonamide (Compound FY) (67 mg, yield: 8%).

Workup

customThe solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (chloroform/methanol=1/0 to 4/1)

Sources & evidence

ORD record: ord-22bd993e975f4c84a3466d7556407976
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08673908B2

Reaction notes

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