Methylamine → Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl-

HRID 1186463Notes

Reaction equation

HRID 1186463 reaction equation
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=[N:4][CH:3]=1.[CH3:12][NH2:13]>CCO>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:13][CH3:12])[C:5]2=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 100598493-Bromo-8-chloroimidazo[1,2-a]pyrazine

Product 1

HCID 3088360Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine was prepared by a process analogous to that described in Example 2 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine and excess methylamine (33% weight in EtOH) at room temperature in EtOH.

Sources & evidence

ORD record
ord-27585390005d406b9c863723c9d1e49b
Source dataset
uspto-grants-2014_03
Patent number
US08673905B2

Reaction notes

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