反应详情

Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine was prepared by a process analogous to that described in Example 12 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine (from Example 1 supra), 4-amino-piperidine-1-carboxylic acid tert-butyl ester, 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 395.4.