4-Aminotetrahydropyran → Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine

Participants

Role	Name	HCID	Charge
Reactant	4-Aminotetrahydropyran	HCID 419223	—
Reactant	4-Amino-1-Boc-piperidine	HCID 1268291	—
Reactant	2-(Methylthio)-4-(tributylstannyl)pyrimidine	HCID 2763261	—
Reactant	3-Bromo-8-chloroimidazo[1,2-a]pyrazine	HCID 10059849	—
Product	Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine	HCID 66548258	—

Reaction Steps

Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine was prepared by a process analogous to that described in Example 12 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine (from Example 1 supra), 4-amino-piperidine-1-carboxylic acid tert-butyl ester, 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 395.4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673905B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-d81abd5f0c3a45808e959d085b5e0fee
Source note	uspto-grants-2014_03