Methylamine → HCID 66548261, compound

HRID 1186480Notes

Reaction equation

HRID 1186480 reaction equation
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=[N:4][CH:3]=1.C(OC([N:19]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]1)=O)(C)(C)C.CS[C:28]1[N:33]=[C:32]([Sn](CCCC)(CCCC)CCCC)[CH:31]=[CH:30][N:29]=1.[CH3:47][NH2:48]>>[CH3:47][NH:48][C:28]1[N:33]=[C:32]([C:2]2[N:6]3[CH:7]=[CH:8][N:9]=[C:10]([NH:25][CH:22]4[CH2:21][CH2:20][NH:19][CH2:24][CH2:23]4)[C:5]3=[N:4][CH:3]=2)[CH:31]=[CH:30][N:29]=1

Participants

5

Reactant 4

HCID 6329MethylamineHCID 12682914-Amino-1-Boc-piperidineHCID 27632612-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 100598493-Bromo-8-chloroimidazo[1,2-a]pyrazine

Product 1

HCID 66548261HCID 66548261, compound

Procedure

[3-(2-Methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-piperidin-4-yl-amine was prepared by a process analogous to that described in Example 12 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine (from Example 1 supra), 4-amino-piperidine-1-carboxylic acid tert-butyl ester, 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and methylamine. LC-MS: [M+H]+ 325.3.

Sources & evidence

ORD record
ord-d83fa76f8acb4593b844527fcce581aa
Source dataset
uspto-grants-2014_03
Patent number
US08673905B2

Reaction notes

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