Triethylamine → HCID 68671320, compound

HRID 1186582Notes

Reaction equation

HRID 1186582 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:41]=[C:42]([F:44])[CH:43]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:10]=[C:9]2[NH:34]C(=O)C(F)(F)F.C(N(CC)CC)C>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:41]=[C:42]([F:44])[CH:43]=1)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[N:11]([C:15]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[N:10]=[C:9]2[NH2:34]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 86647616HCID 86647616, compound

Product 1

HCID 68671320HCID 68671320, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[5-(3,5-Difluoro-benzyl)-1-trityl-1H-indazol-3-yl]-2,2,2-trifluoro-acetamide (450 mg, 0.75 mmol) was dissolved in methanol (6 mL) and triethylamine (1.5 mL) and the solution was refluxed for 3 hours. The solvents were removed under reduced pressure and the residue was purified by flash chromatography (eluant: DCM). Title compound was isolated as white foam (300 mg, yield 80%).

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was purified by flash chromatography (eluant: DCM)

Sources & evidence

ORD record
ord-a6511d7c202d4621894e0936e6bb3596
Source dataset
uspto-grants-2014_03
Patent number
US08673893B2

Reaction notes

Loading…