Sodium Hydroxide → HCID 21973614, compound

HRID 11866Notes

Reaction equation

HRID 11866 reaction equation
C[C:2]1[CH:11]=[C:10]([CH2:12][N:13]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:28]([OH:30])=[O:29].[OH-].[Na+]>C1COCC1.CO>[C:21]([N:13]([CH2:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:28]([OH:30])=[O:29])=[CH:2][CH:11]=1)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 21973685HCID 21973685, compound

Product 1

HCID 21973614HCID 21973614, compoundYield 87.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The compound obtained in Example 43-1 (1.60 g) was dissolved in THF (16 ml) and methanol (16 ml). After the addition of 1 mol/l aqueous solution of sodium hydroxide (16 ml), the mixture was stirred for 16 hours at room temperature. After the reaction, the solvent was removed by distillation. The residue was dissolved in distilled water and 1 mol/l aqueous solution of hydrochloric acid was added to produce a precipitate. The precipitate was collected by filtration and dried to obtain the title compound (1.3537 g) as a white solid.

Workup

  1. customAfter the reaction
  2. customthe solvent was removed by distillation
  3. dissolutionThe residue was dissolved in distilled water
  4. addition1 mol/l aqueous solution of hydrochloric acid was added
  5. customto produce a precipitate
  6. filtrationThe precipitate was collected by filtration
  7. customdried

Sources & evidence

ORD record
ord-41eeeb2ebe654f5880ffb7bc1398ddda
Source dataset
uspto-grants-2006_08
Patent number
US07098215B2

Reaction notes

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