反应详情

The compound obtained in Example 43-1 (1.60 g) was dissolved in THF (16 ml) and methanol (16 ml). After the addition of 1 mol/l aqueous solution of sodium hydroxide (16 ml), the mixture was stirred for 16 hours at room temperature. After the reaction, the solvent was removed by distillation. The residue was dissolved in distilled water and 1 mol/l aqueous solution of hydrochloric acid was added to produce a precipitate. The precipitate was collected by filtration and dried to obtain the title compound (1.3537 g) as a white solid.

1. customAfter the reaction
2. customthe solvent was removed by distillation
3. dissolutionThe residue was dissolved in distilled water
4. addition1 mol/l aqueous solution of hydrochloric acid was added
5. customto produce a precipitate
6. filtrationThe precipitate was collected by filtration
7. customdried