4-Amino-N-(2-methylphenyl)benzenesulfonamide → HCID 43257989, compound

HRID 1186650Notes

Reaction equation

HRID 1186650 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:19][O:20]C1C=C([N+]([O-])=O)C=CC=1S(NC1C=CC(C)=CC=1)(=O)=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])(=[O:10])=[O:9])=[C:4]([O:20][CH3:19])[CH:3]=1

Participants

3

Reactant 2

HCID 5935694-Amino-N-(2-methylphenyl)benzenesulfonamideHCID 58398228HCID 58398228, compound

Product 1

HCID 43257989HCID 43257989, compoundYield 93%

Procedure

(RK2-065-01) I This compound was prepared according to the procedure described for compound 12a except using 11j to obtain the required product as a yellow solid (63 mg, 93%). Mp=189-191° C.; 1H NMR (400 MHz, CD3OD) δ 7.30 (d, J=8.8 Hz, 1H), 7.10-7.06 (m, 2H), 7.01-6.97 (m, 2H), 6.31 (d, J=1.6 Hz, 1H), 6.12 (dd, J=8.8, 2.0 Hz, 1H), 3.30 (s, 3H), 2.22 (s, 3H).

Workup

  1. custom(RK2-065-01) I This compound was prepared

Sources & evidence

ORD record
ord-0eee0e44ebdc4c94977049b5662d4202
Source dataset
uspto-grants-2014_03
Patent number
US08673910B2

Reaction notes

Loading…