Ethyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetate → N-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamide

HRID 1186669Notes

Reaction equation

HRID 1186669 reaction equation
OC1C2C(=CC=CC=2)C(NS(C2SC=CC=2)(=O)=O)=CC=1SCC(OCC)=O.[CH:28]1([NH:31][C:32](=[O:56])[CH2:33][CH2:34][S:35][C:36]2[C:37](=[O:55])[C:38]3[C:43]([C:44](=[N:46][S:47]([C:50]4[S:51][CH:52]=[CH:53][CH:54]=4)(=[O:49])=[O:48])[CH:45]=2)=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:32](=[O:56])[CH2:33][CH2:34][S:35][C:36]2[CH:45]=[C:44]([NH:46][S:47]([C:50]3[S:51][CH:52]=[CH:53][CH:54]=3)(=[O:48])=[O:49])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:37]=2[OH:55])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 44608823Ethyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetateHCID 67330263N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide

Product 1

HCID 44609144N-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamide

Procedure

5.2.51 N-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamide (14h) was prepared according to the procedure for 9a except using 13h affording 8.8 mg (89%) title compound, m.p.: ° C.

Sources & evidence

ORD record
ord-b36a72715ae246589cf97b6c5b5a0817
Source dataset
uspto-grants-2014_03
Patent number
US08673910B2

Reaction notes

Loading…