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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1186669Generated: October 25, 2026

Ethyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetate → N-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamide

https://huagongshe.com/reaction/1186669

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetateHCID 44608823—
ReactantN-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamideHCID 67330263—
ProductN-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamideHCID 44609144—

Reaction Steps

5.2.51 N-cyclopropyl-3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanamide (14h) was prepared according to the procedure for 9a except using 13h affording 8.8 mg (89%) title compound, m.p.: ° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673910B2
Source datasetuspto-grants-2014_03
ORD IDord-b36a72715ae246589cf97b6c5b5a0817
Source noteuspto-grants-2014_03