2-Mercaptobenzoic Acid → 2-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)benzoic acid

HRID 1186672Notes

Reaction equation

HRID 1186672 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][S:13]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)(=[O:15])=[O:14])=[CH:4][C:3]=1[S:21]CC(O)=O.[C:26]([OH:35])(=[O:34])[C:27]1[C:28](=[CH:30][CH:31]=[CH:32][CH:33]=1)S>>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][S:13]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:15])=[CH:4][C:3]=1[S:21][C:33]1[CH:32]=[CH:31][CH:30]=[CH:28][C:27]=1[C:26]([OH:35])=[O:34]

Participants

3

Reactant 2

HCID 54432-Mercaptobenzoic AcidHCID 15826052-{[1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yl]sulfanyl}acetic acid

Product 1

HCID 446091452-(1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)benzoic acid

Procedure

5.2.54 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)benzoic acid (14l) was prepared according to the procedure of procedure B for 10a except using thiosalicylic acid, which afforded the title compound 19 mg (99%) as a white solid, m.p.: 215° C. (dec.).

Sources & evidence

ORD record
ord-73902e3694fe4680a9ae54b94b11702d
Source dataset
uspto-grants-2014_03
Patent number
US08673910B2

Reaction notes

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