HRID1186680

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5443

2-Thiosalicylic acid

C7H6O2S

结构：O=C(O)CSc1cc(NS(=O)(=O)c2cccs2)c2ccccc2c1O

HCID1582605

未命名化合物

$结构：O=C1C(Cl)=C/C(=N\S(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc21$

HCID58398230

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1ccccc1Sc1cc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccccc2c1O

HCID44609308

未命名化合物

PROCEDURE

实验过程

5.2.62 2-(4-(biphenyl-4-ylsulfonamido)-1-hydroxynaphthalen-2-ylthio)benzoic acid (14t) was prepared according to the procedure of procedure B for 10a except using 2-thiosalicylic acid and (E)-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)biphenyl-4-sulfonamide (12b), which afforded the title compound 17.4 mg (65.9%) as an off-white solid, m.p.: 205° C. (dec.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-44a9883ad1c544baa052de2937dc4d7f
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08673910B2
来源说明: uspto-grants-2014_03

反应 SMILES

OC1C2C(=CC=CC=2)C(NS(C2SC=CC=2)(=O)=O)=CC=1SCC(O)=O.[CH:26]1[CH:31]=[C:30]([C:32]([OH:34])=[O:33])[C:29]([SH:35])=[CH:28][CH:27]=1.Cl[C:37]1[C:46](=[O:47])[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)/[C:39](=[N:48]/[S:49]([C:52]2[CH:57]=[CH:56][C:55]([C:58]3[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=3)=[CH:54][CH:53]=2)(=[O:51])=[O:50])/[CH:38]=1>>[C:55]1([C:58]2[CH:59]=[CH:60][CH:61]=[CH:62][CH:63]=2)[CH:56]=[CH:57][C:52]([S:49]([NH:48][C:39]2[C:40]3[C:45](=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:46]([OH:47])=[C:37]([S:35][C:29]3[CH:28]=[CH:27][CH:26]=[CH:31][C:30]=3[C:32]([OH:34])=[O:33])[CH:38]=2)(=[O:51])=[O:50])=[CH:53][CH:54]=1