Trifluoroacetic acid → HCID 66864132, compound

HRID 1186692Notes

Reaction equation

HRID 1186692 reaction equation
[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=2)[C:2]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:10]([O:9][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([OH:20])=[O:19])[CH:13]=1)=[O:8])[CH3:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66863761HCID 66863761, compound

Product 1

HCID 66864132HCID 66864132, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3′-tert-butyl 2-ethyl biphenyl-2,3′-dicarboxylate 55 (0.2 g, 0.613 mmol) in DCM (2 ml), trifluoroacetic acid (0.472 ml, 6.13 mmol) was added and stirred at rt for 5 h. It was then concentrated in vacuo, taken up in DCM and concentrated again (2×). The crude compound was then dried overnight on the vacuum pump to afford compound 56 (0.166 g, 100% yield) as a white solid.

Workup

  1. concentrationIt was then concentrated in vacuo
  2. concentrationconcentrated again (2×)
  3. dry with materialThe crude compound was then dried overnight on the vacuum pump

Sources & evidence

ORD record
ord-22cca2cb4c8d4a8d9551ac742a02d9a7
Source dataset
uspto-grants-2014_03
Patent number
US08673911B2

Reaction notes

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