HCID 58121056, compound → tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamate

HRID 1186693Notes

Reaction equation

HRID 1186693 reaction equation
ONC(=O)C1C=CC=CC=1C#CC1C=CC=CC=1.[N+:19]([C:22]1[CH:27]=[C:26]([C:28]2[S:29][CH:30]=[CH:31][CH:32]=2)[CH:25]=[CH:24][C:23]=1[NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])([O-])=O>>[NH2:19][C:22]1[CH:27]=[C:26]([C:28]2[S:29][CH:30]=[CH:31][CH:32]=2)[CH:25]=[CH:24][C:23]=1[NH:33][C:34](=[O:40])[O:35][C:36]([CH3:38])([CH3:37])[CH3:39]

Participants

3

Reactant 2

HCID 58121056HCID 58121056, compoundHCID 59736984tert-Butyl 2-nitro-4-(thiophen-2-yl)phenylcarbamate

Product 1

HCID 57717474tert-Butyl (2-amino-4-(thiophen-2-yl)phenyl)carbamateYield 92%

Procedure

The procedure was followed as outlined in Scheme 3, Step 3 replacing compound 37 with compound 60 to afford tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate 61 (2.75 g, 92% yield) as a yellow solid. LRMS (ESI): (calc.) 290.11 (found) 235.1 (M(-tBu)Na)+

Sources & evidence

ORD record
ord-5a9b0b950b6b4e85b83360c53dd80503
Source dataset
uspto-grants-2014_03
Patent number
US08673911B2

Reaction notes

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