Methyl 2-bromo-5-methoxybenzoate → HCID 58121105, compound

HRID 1186704Notes

Reaction equation

HRID 1186704 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9](OC)=[CH:8][C:3]=1C(OC)=O.Cl[C:15]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[S:17][C:16]=1[C:26]([O:28][CH3:29])=[O:27]>>[C:2]1([C:15]2[CH:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[S:17][C:16]=2[C:26]([O:28][CH3:29])=[O:27])[CH:11]=[CH:10][CH:9]=[CH:8][CH:3]=1

Participants

3

Reactant 2

HCID 2776849Methyl 2-bromo-5-methoxybenzoateHCID 58121069HCID 58121069, compound

Product 1

HCID 58121105HCID 58121105, compoundYield 90%

Procedure

The procedure was followed as outlined in Scheme 2, Step 1 replacing compounds 8 and 9 with compounds 83 and 84 to afford methyl 3,5-diphenylthiophene-2-carboxylate 85 (90% yield) as a white solid after purification by ISCO (12 g column, 0 to 30% ethyl acetate in hexane). LRMS (ESI): (calc) 294.37 (found) 295.21 (MH)+

Sources & evidence

ORD record
ord-5d98b22541e741079afee4195bf6f0bd
Source dataset
uspto-grants-2014_03
Patent number
US08673911B2

Reaction notes

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