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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1186712Generated: November 2, 2026

Hydrochloric Acid → Methyl 5-(hydroxymethyl)-3-phenylthiophene-2-carboxylate

https://huagongshe.com/reaction/1186712

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethyl 5-((tert-butyldimethylsilyloxy)methyl)-3-phenylthiophene-2-carboxylateHCID 66863649—
SolventMethanolHCID 887—
ProductMethyl 5-(hydroxymethyl)-3-phenylthiophene-2-carboxylateHCID 58121059—

Reaction Steps

To a solution of 168 (6.389 g, 17.62 mmol) in 93 mL of MeOH was added concentrated HCl

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673911B2
Source datasetuspto-grants-2014_03
ORD IDord-40bf6ae8f61f44f4a4d355df2e0a1b08
Source noteuspto-grants-2014_03