Hydrochloric Acid → Methyl 5-(hydroxymethyl)-3-phenylthiophene-2-carboxylate

HRID 1186712Notes

Reaction equation

HRID 1186712 reaction equation
[Si]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15]([O:17][CH3:18])=[O:16])=[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:11]=1)(C(C)(C)C)(C)C.Cl>CO>[OH:8][CH2:9][C:10]1[S:14][C:13]([C:15]([O:17][CH3:18])=[O:16])=[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66863649Methyl 5-((tert-butyldimethylsilyloxy)methyl)-3-phenylthiophene-2-carboxylate

Product 1

HCID 58121059Methyl 5-(hydroxymethyl)-3-phenylthiophene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 168 (6.389 g, 17.62 mmol) in 93 mL of MeOH was added concentrated HCl

Sources & evidence

ORD record
ord-40bf6ae8f61f44f4a4d355df2e0a1b08
Source dataset
uspto-grants-2014_03
Patent number
US08673911B2

Reaction notes

Loading…