o-Iodophenylacetyl chloride → 4-[3-[(2-Iodophenylacetyl)amino]phenyl)-1,4-dihydrobenzo[f]quinoxaline-2,3-dione
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[CH:16]=[CH:15][C:14]4[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=4[C:12]=3[NH:11][C:10](=[O:22])[C:9]2=[O:23])[CH:5]=[CH:6][CH:7]=1.[I:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][C:32](Cl)=[O:33]>>[I:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH2:31][C:32]([NH:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[CH:16]=[CH:15][C:14]4[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=4[C:12]=3[NH:11][C:10](=[O:22])[C:9]2=[O:23])[CH:5]=[CH:6][CH:7]=1)=[O:33]Participants
3
Procedure
4-(3-Aminophenyl)-1,4-dihydrobenzo[f]quinoxaline-2,3-dione (30 mg, 0.1 mmol) and 2-iodophenylacetylchloride were used in a process similar to Example 9 to give the titled compound as a yellow crystal (6 mg, yield 11%).
Sources & evidence
- ORD record
- ord-fd91863711a74f5aa3192320e567c25c
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08673915B2
Reaction notes
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